Biophysical Approaches for Drug Discovery

Biophysical technologies, which detect molecules physically interacting with one another, are now employed in drug discovery more than ever. This is because researchers are more actively searching for new therapeutic candidates different from classical enzyme inhibitors, which requires moving beyond biochemical assays that detect enzyme/inhibitor activity. Detection of inhibitors of protein complexes (PPI inhibitors) or fragment-based drug leads needs biophysical assays such as those based on nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR).

Further propelling biophysical techniques to the fore are advances in their throughput making them more amenable to compound library screening applications. Learn from and network with fellow drug discovery biophysicists, structural biologists and computational and medicinal chemists to discuss advances, hear examples of, and learn new applications of biophysical technologies in the endeavor of finding new drug leads. Other methods that may not be ‘pure biophysical’ but are new and not biochemical-based will also be a part of the program. Another focus of the meeting will be to highlight and discuss integration of various approaches and deciding ‘when to use what’ depending on a project’s needs.

  • New Methods for Medicinal Chemists

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